Publication

  • Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
  • Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
  • Veerapandian V, Ackermann JO, Srivastava Y… Yang X, Jauch R. (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
  • Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
  • Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
  • Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
  • Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
  • Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090

Publication

  • Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29 (539): 102-106. https://doi.org/10.1038/nature20105
  • CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312.  https://doi.org/10.1016/j.yexcr.2017.02.017 
  • Lee JC, Biasci D, Roberts R… Mansfield  Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268.  https://doi.org/10.1038/ng.3755 
  • Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27 (12): 1466-1484.  https://doi.org/10.1038/cr.2017.127 
  • IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212.  http://dx.doi.org/10.1016/j.canlet.2018.05.044  
  • Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123. https://doi.org/10.1073/pnas.1811866115
  • Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgfsignaling in planar cell polarity. Development 145 (8). https://doi.org/10.1242/dev.163824
  • Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148 
  • Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
  • Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions. Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013

Official Collaborated with:

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Centre for Translational Stem Cell Biology  

幹細胞轉化研究中心

EPSCs for Genomic Medicine of Immune Disease

Apply EPSCs technology to study immunological disorders  focusing on autoimmunity and primary immunodeficiency, and develop drug target discovery for immunological disorders

  • Using somatic cells from patients and healthy subjects for EPSC cell lines generation
  • Transduce normal human EPSC cell lines with disease-associated genetic variants
  • Differentiation of immune cells and tissue organoids from patient and isogenic EPSC cell lines for modelling disease pathogenesis and drug screening
Project Team Members
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Professor Chak Sing LAU

Programme Leader
Dress shirt, Forehead, Nose, Smile, Tie, Jaw, Sleeve, Gesture, Collar

Professor Ken SMITH

Programme Leader
Vision care, Dress shirt, Glasses, Chin, Sleeve, Eyewear, Collar

Professor Pengtao LIU

Managing Director

Professor Gordon DOUGAN

Co-Director
Smile

Prof. Menna CLATWORTHY

Principal Investigator
Dress shirt, Hair, Smile, Outerwear, Neck, Sleeve, Gesture, Collar

Dr. Vera CHAN

Principal Investigator
People in nature, Facial expression, Clothing, Smile, Joint, Hand, Hairstyle, Shoulder, Arm, Plant

Dr. María DUQUE-CORREA

Principal Investigator
Dress shirt, Street fashion, Clothing, Shoe, Leg, Sleeve, Comfort, Collar, Knee, Eyewear

Professor Bo GAO

Principal Investigator
Dress shirt, Smile, Sleeve, Collar

Professor Ralf JAUCH

Principal Investigator
Dress shirt, Forehead, Hair, Chin, Smile, Hairstyle, Tartan, Beard, Jaw

Dr. Ricky LAU

Post-Doctoral Fellow
Human body, Dress shirt, Smile, Arm, Shoulder, Neck, Sleeve, Gesture, Collar

Dr. Xueyan LIU

Post-Doctoral Fellow
Face, Forehead, Nose, Hair, Cheek, Chin, Eyebrow, Eye, Jaw, Eyelash

Dr. Luyao MA

Post-Doctoral Fellow
Vision care, Dress shirt, Forehead, Face, Glasses, Lip, Chin, Outerwear, Shoulder, Neck

Dr. April Thi Thuy NGUYEN

Post-Doctoral Fellow
Dress shirt, Clothing, Outerwear, Smile, Neck, Sleeve, Gesture, Collar

Wenxin JIANG

Research Assistant
Flash photography, Forehead, Nose, Cheek, Lip, Azure, Neck, Jaw, Sleeve, Eyelash

Pengyu CHEN

Research Assistant
Dress shirt, School uniform, Clothing, Hair, Smile, Neck, Sleeve, Gesture, Collar, Elbow

Chung Sze OR

PhD Student
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Suey Yuqing SU

Research Assistant
Vision care, Dress shirt, Hair, Glasses, Outerwear, Tie, Neck, Sleeve, Gesture, Collar

Tony Yuebin TAN

PhD Student
Dress shirt, Joint, Lip, Smile, Outerwear, Shoulder, Coat, Neck, Sleeve, Gesture

Faria Tin Wai TSUI

Research Assistant
Flash photography, Clothing, Forehead, Smile, Cheek, Skin, Lip, Chin, Outerwear, Eyebrow

Martha Shi Wing YEUNG

Research Assistant
Dress shirt, Forehead, Face, Chin, Eyebrow, Eyelash, Jaw, Neck, Sleeve

Shijia XIA

Research Assistant
Selected Publication
  1.  Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions.Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013
  2. Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
  3. Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148
  4.  Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity. Development 145(8).  https://doi.org/10.1242/dev.163824
  5.  Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123.
  6. IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212. http://dx.doi.org/10.1016/j.canlet.2018.05.044
  7.  Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27(12): 1466-1484. https://doi.org/10.1038/cr.2017.127
  8. Lee JC, Biasci D, Roberts R… Mansfield  Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268. https://doi.org/10.1038/ng.3755
  9. CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312.  https://doi.org/10.1016/j.yexcr.2017.02.017
  10. Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29(539): 102-106. https://doi.org/10.1038/nature20105
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