Official Collaborated with:

New Stem Cell Technology
CTSCB aims to develop new human cell lineage knowledge to optimize protocols for efficient generation of specific cell types from human Expanded Potential Stem Cells (EPSCs).
- New technology relevant to stem cells with totipotency features
- Molecular determinants in direct differentiation of expanded potential stem cells (EPSCs) to functional cells
- Genome editing of EPSCs and new genome editing techniques and applications in ES cells
- Protein engineering and direct molecular evolution
Project Team Members

Professor Pengtao LIU
Managing Director & Programme Leader

Professor Bertie Göttgens
Programme Co-Leader

Professor William YEUNG
Principal Investigator

Professor Yuanhua HUANG
Principal Investigator

Dr. Ralf JAUCH
Principal Investigator

Dr. Cherie LEE
Principal Investigator

Dr. Stephanie MA
Principal Investigator

Professor Rio SUGIMURA
Principal Investigator

Professor Fang LIU
Senior Scientific Director

Dr. Hui LIU
Head of Technology (Antibody)

Dr. Dominik SPENSBERGER
Head of Technology (Genome Engineering)

Dr. Dirk ZAHN
Head of Technology (Single-Domain Antibody)

Dr. Degong RUAN
Junior Principal Investigator

Dr. Guocheng LAN
Principal Researcher

Dr. Chris Yuk Kam CHEUNG
Assistant Research Officer

Dr. Melania BARILE
Post-Doctoral Fellow

Dr. Feng ZHEN
Post-Doctoral Fellow

Dr. Jilong GUO
Post-Doctoral Fellow

Dr. Yingzhang HUANG
Post-Doctoral Fellow

Dr. Nicole Tianqi LI
Post-Doctoral Fellow

Dr. Qingqing LIU
Post-Doctoral Fellow

Dr. April Thi Thuy NGUYEN
Post-Doctoral Fellow

Dr. Hanzhang RUAN
Post-Doctoral Fellow

Dr. Weiyu ZHANG
Post-Doctoral Fellow

Kenso SO
Senior Technical Officer

Dr. Guoliang WANG
Senior Technical Officer

Dr. Yiyi XUAN
Post-Doctoral Fellow

Yiming CHAO
PhD Student

Chen CHENG
MPhil Student

Ziwei HE
PhD Student

Cindy HU
MPhil Student

Wenxin JIANG
Research Assistant

Angie Man Ping LEE
Research Assistant

Lu LIU
Research Assistant

Xianjie HUANG
PhD Student

Danny LI
Research Assistant

Daniel Ming Hon LU
Research Assistant

Lihao SHAO
Research Assistant

Wendy Cheuk Ying TIU
Research Associate

Timothy WONG
Research Assistant

Xiao WANG
MPhil Student

Vivian Tsz Wan WONG
Research Assistant

Shao XU
Research Assistant

Claire Woojeong YANG
Research Assistant

Yunzhi YANG
Research Assistant

Sophronia YIP
Research Assistant

Anna Xiaoyi ZHANG
Research Assistant

Shihui ZHANG
PhD Student

Dr. Andy Chun Hang CHAN
Honorary Research Associate
Selected Publication
- Tan DS, Chen Y, Gao Y, Bednarz A, Wei Y, Malik V, Ho DH, Weng M, Ho SY, Srivastava Y, Velychko S, Yang X, Fan L, Kim J, Graumann J, Stormo GD, Braun T, Yan J, Scholer HR, Jauch R (2021) Directed Evolution of an Enhanced POU Reprogramming Factor for Cell Fate Engineering. Mol Biol Evol. 38: 2854-2868 https://doi.org/10.1093/molbev/msab075
- Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090
- Malik V, Glaser LV, Zimmer D, Velychko S, Weng M, Holzner M, Arend M, Chen Y, Srivastava Y, Veerapandian V, Shah Z, Esteban MA, Wang H, Chen J, Scholer HR, Hutchins AP, Meijsing SH, Pott S, Jauch R (2019) Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2. Nat Commun. 10: 3477. https://doi.org/10.1038/s41467-019-11054-7
- Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
- Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
- Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
- Veerapandian V, Ackermann JO, Srivastava Y, Malik V, Weng M, Yang X, Jauch R (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports. 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
- Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
- Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
- Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
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