Publication

  • Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
  • Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
  • Veerapandian V, Ackermann JO, Srivastava Y… Yang X, Jauch R. (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
  • Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
  • Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
  • Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
  • Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
  • Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090

Publication

  • Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29 (539): 102-106. https://doi.org/10.1038/nature20105
  • CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312.  https://doi.org/10.1016/j.yexcr.2017.02.017 
  • Lee JC, Biasci D, Roberts R… Mansfield  Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268.  https://doi.org/10.1038/ng.3755 
  • Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27 (12): 1466-1484.  https://doi.org/10.1038/cr.2017.127 
  • IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212.  http://dx.doi.org/10.1016/j.canlet.2018.05.044  
  • Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123. https://doi.org/10.1073/pnas.1811866115
  • Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgfsignaling in planar cell polarity. Development 145 (8). https://doi.org/10.1242/dev.163824
  • Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148 
  • Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
  • Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions. Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013

Official Collaborated with:

Material property, Azure, Aqua

Centre for Translational Stem Cell Biology  

幹細胞轉化研究中心

New Stem Cell Technology

CTSCB aims to develop new human cell lineage knowledge to optimize protocols for efficient generation of specific cell types from human Expanded Potential Stem Cells (EPSCs).

  • New technology relevant to stem cells with totipotency features
  • Molecular determinants in direct differentiation of expanded potential stem cells (EPSCs) to functional cells
  • Genome editing of EPSCs and new genome editing techniques and applications in ES cells
  • Protein engineering and direct molecular evolution
Project Team Members
Vision care, Dress shirt, Glasses, Chin, Sleeve, Eyewear, Collar

Professor Pengtao LIU

Managing Director & Programme Leader
Dress shirt, Forehead, Smile, Cheek, Head, Chin, Eyebrow, Jaw, Sleeve, Collar

Professor Bertie Göttgens

Programme Co-Leader
Dress shirt, White coat, Human body, Glasses, Smile, Workwear, Sleeve, Gesture, Collar

Professor William YEUNG

Principal Investigator
Dress shirt, Human body, Forehead, Chin, Neck, Jaw, Sleeve, Gesture, Collar

Professor Yuanhua HUANG

Principal Investigator
Dress shirt, Smile, Sleeve, Collar

Dr. Ralf JAUCH

Principal Investigator
White coat, Dress shirt, Human body, Smile, Arm, Shoulder, Eye, Neck, Sleeve

Dr. Cherie LEE

Principal Investigator
Street fashion, Dress shirt, Flash photography, Face, Smile, Leg, Neck, Sleeve, Standing, Waist

Dr. Stephanie MA

Principal Investigator
Vision care, Polo shirt, Flash photography, Glasses, Watch, Joint, Shoulder, Neck, Sleeve

Professor Rio SUGIMURA

Principal Investigator
Dress shirt, Human body, White coat, Outerwear, Neck, Sleeve, Gesture, Collar

Professor Fang LIU

Senior Scientific Director
White coat, Dress shirt, Human body, Health care, Face, Workwear, Neck, Sleeve, Gesture, Collar

Dr. Hui LIU

Head of Technology (Antibody)
Forehead, Nose, Cheek, Chin, Jaw

Dr. Dominik SPENSBERGER

Head of Technology (Genome Engineering)
Forehead

Dr. Dirk ZAHN

Head of Technology (Single-Domain Antibody)
Dress shirt, Human body, Face, Hair, Head, Chin, Neck, Sleeve, Gesture, Workwear

Dr. Degong RUAN

Junior Principal Investigator
Dress shirt, Human body, White coat, Face, Glasses, Smile, Neck, Sleeve, Gesture, Collar

Dr. Guocheng LAN

Principal Researcher
Forehead, Nose, Smile, Cheek, Jaw, Eyelash, Gesture, Happy

Dr. Chris Yuk Kam CHEUNG

Assistant Research Officer
Human body, Hair, Smile, Jeans, Arm, Shoulder, Neck, Sleeve, Gesture, Grey

Dr. Melania BARILE

Post-Doctoral Fellow
Face, Joint, Head, Outerwear, Shoulder, Azure, Neck, Smile, Sleeve, Gesture

Dr. Feng ZHEN

Post-Doctoral Fellow
Dress shirt, Human body, Forehead, Hair, Cheek, Chin, Eyebrow, Eye, Tie, Sleeve

Dr. Jilong GUO

Post-Doctoral Fellow
Vision care, Clothing, Forehead, Glasses, Cheek, Smile, Outerwear, Eyebrow, Eyewear, Neck

Dr. Yingzhang HUANG

Post-Doctoral Fellow
Clothing, Hair, Chin, Eyebrow, Sleeve, Tie, Collar, Gesture

Dr. Nicole Tianqi LI

Post-Doctoral Fellow
Dress shirt, Forehead, Face, Nose, Cheek, Lip, Smile, Eye, Eyebrow, Shoulder

Dr. Qingqing LIU

Post-Doctoral Fellow
Vision care, Dress shirt, Forehead, Face, Glasses, Lip, Chin, Outerwear, Shoulder, Neck

Dr. April Thi Thuy NGUYEN

Post-Doctoral Fellow
Forehead, Cheek, Chin, Eyebrow, Eyelash, Neck, Jaw, Sleeve, Gesture, Collar

Dr. Hanzhang RUAN

Post-Doctoral Fellow
Dress shirt, Human body, White coat, Clothing, Hair, Face, Joint, Arm, Shoulder, Neck

Dr. Weiyu ZHANG

Post-Doctoral Fellow
Dress shirt, Human body, White coat, Hair, Face, Head, Neck, Sleeve, Gesture, Collar

Kenso SO

Senior Technical Officer
Dress shirt, Forehead, Hair, Nose, Cheek, Lip, Chin, Hairstyle, Eyebrow, Eyelash

Dr. Guoliang WANG

Senior Technical Officer
Flash photography, Forehead, Nose, Cheek, Lip, Eyebrow, Eyelash, Neck, Jaw, Gesture

Dr. Yiyi XUAN

Post-Doctoral Fellow
Dress shirt, White coat, Face, Hair, Smile, Neck, Sleeve, Gesture, Collar

Yiming CHAO

PhD Student
Human body, Hair, Head, Shoulder, Neck, Sleeve, Gesture, Collar, Jacket

Chen CHENG

MPhil Student
Dress shirt, Vision care, Human body, Glasses, Smile, Outerwear, Arm, Shoulder, Neck, Coat

Ziwei HE

PhD Student
Dress shirt, Smile, Outerwear, Neck, Sleeve, Gesture, Collar

Cindy HU

MPhil Student
Dress shirt, Clothing, Outerwear, Smile, Neck, Sleeve, Gesture, Collar

Wenxin JIANG

Research Assistant
Vision care, Forehead, Glasses, Nose, Cheek, Skin, Lip, Chin, Outerwear, Smile

Angie Man Ping LEE

Research Assistant
Dress shirt, Clothing, Forehead, Nose, Cheek, Lip, Chin, Eye, Jaw, Eyelash

Lu LIU

Research Assistant
Dress shirt, Human body, Outerwear, Coat, Neck, Sleeve, Gesture, Collar, Suit

Xianjie HUANG

PhD Student
Dress shirt, White coat, Face, Smile, Neck, Sleeve, Gesture, Collar

Danny LI

Research Assistant
Forehead, Nose, Cheek, Eyebrow, Jaw, Eyelash, Gesture

Daniel Ming Hon LU

Research Assistant
Vision care, Dress shirt, Forehead, Glasses, Cheek, Smile, Chin, Eyebrow, Eye, Eyewear

Lihao SHAO

Research Assistant
Forehead, Nose, Cheek, Lip, Chin, Eyelash, Jaw, Neck, Sleeve, Gesture

Wendy Cheuk Ying TIU

Research Associate
Dress shirt, Face, Smile, Head, Jaw, Neck, Sleeve, Gesture, Collar

Timothy WONG

Research Assistant
Vision care, Dress shirt, Forehead, Glasses, Chin, Eyebrow, Tie, Gesture, Collar, Suit

Xiao WANG

MPhil Student
Flash photography, Smile, Cheek, Lip, Jaw, Sleeve, Gesture, Happy

Vivian Tsz Wan WONG

Research Assistant
White coat, Dress shirt, Human body, Hair, Glasses, Smile, Arm, Neck, Workwear, Sleeve

Shao XU

Research Assistant
Dress shirt, Human body, Hairstyle, Shoulder, Coat, Smile, Neck, Sleeve, Gesture, Collar

Claire Woojeong YANG

Research Assistant
Facial expression, Flash photography, Forehead, Cheek, Skin, Lip, Chin, Eyebrow, Eyelash, Neck

Yunzhi YANG

Research Assistant
Dress shirt, Smile, Shoulder, Neck, Sleeve, Gesture, Collar

Sophronia YIP

Research Assistant
Dress shirt, Hair, Lip, Chin, Eyebrow, Neck, Jaw, Sleeve, Gesture, Collar

Anna Xiaoyi ZHANG

Research Assistant
White coat, Dress shirt, Face, Hair, Smile, Glasses, Sleeve, Gesture, Collar

Shihui ZHANG

PhD Student

Dr. Andy Chun Hang CHAN

Honorary Research Associate
Selected Publication
  1. Tan DS, Chen Y, Gao Y, Bednarz A, Wei Y, Malik V, Ho DH, Weng M, Ho SY, Srivastava Y, Velychko S, Yang X, Fan L, Kim J, Graumann J, Stormo GD, Braun T, Yan J, Scholer HR, Jauch R (2021) Directed Evolution of an Enhanced POU Reprogramming Factor for Cell Fate Engineering. Mol Biol Evol. 38: 2854-2868  https://doi.org/10.1093/molbev/msab075
  2. Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090
  3. Malik V, Glaser LV, Zimmer D, Velychko S, Weng M, Holzner M, Arend M, Chen Y, Srivastava Y, Veerapandian V, Shah Z, Esteban MA, Wang H, Chen J, Scholer HR, Hutchins AP, Meijsing SH, Pott S, Jauch R (2019) Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2. Nat Commun. 10: 3477. https://doi.org/10.1038/s41467-019-11054-7
  4. Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
  5. Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495.  https://doi.org/10.1038/s41586-019-0933-9
  6. Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
  7. Veerapandian V, Ackermann JO, Srivastava Y, Malik V, Weng M, Yang X, Jauch R (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports.  11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
  8. Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
  9. Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
  10. Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
Events / News
Galleries
Board of Directors
Meet Our Team
Centre Overview

Useful Links

Career
info@hkstemcell.hk
(852) 3910 3650

Contact Us

Pipeline
EPSCs for Genomic Medicine
EPSCs for Regenerative Medicine
New Stem Cell Technology

R & D

Rm1105, 11/F, 17W, HKSTP, Shatin, N.T., Hong Kong

Water, Art

Copyright ©2024 All rights reserved | by Centre for Translational Stem Cell Biology