Project 2

Using EPSCs for human cell lineage maps as a framework for regenerative medicine and genetic disorders: Haempotopiesis

Team

Professor Pengtao Liu

HKU
Co-Pls & Collaborators

Professor William Yeung

HKU
Co-Pls & Collaborators

Dr. Cherie Lee

HKU
Co-Pls & Collaborators

Dr. Ralf Jauch

HKU
Co-Pls & Collaborators

Dr. Rio Sugimura

HKU
Co-Pls & Collaborators

Dr. Yuanhua Huang

HKU
Co-Pls & Collaborators

Project Summary

CAR-macrophages to remodel tumor microenvironment

To remodel tumor microenvironment by utilizing hEPSCs derived CAR-Ms via well-known cytokines (IL-12, IL-18, DR-IL 18), immune checkpoint block (PD-1, TGFβ) and knocking out or inhibiting key molecular factors (BTK. PI3Kγ, NOTCH) to control tumor progression. It is expected armed CAR-Ms shift the tumor environment to a proinflammatory state leading to high antitumour efficacy. This will decipher the tumor microenvironment and develop better methods to relieve tumor suffering or cure cancer

The Molecular Switch of Functional Immune Cells In Vitro & In Vivo

To identify molecular switches to harness anti-cancer immune cells using the molecular barcoding and perturb-seq. This will ensure positive response in cancer immunotherapy. Specification of anti-cancer immune cells are expected from human pluripotent stem cells