Human EPSC-derived MSCs will be comprehensively analysed in vitro and in animal models for future clinical applications

One direct clinically relevant application of human EPSCs is translation of human EPSC-derived mesenchymal stem cells (MSCs). MSCs are multipotent stromal cells that have found widespread research application in organ repair and in modulation of a range of immune and inflammatory-mediated conditions. In this project, clinical-grade human EPSC-MSCs will undergo extensive pre-clinical evaluation for safety and efficacy for transplantation in our established clinically relevant models of human heart diseases.